President Joe Biden's pick to head the Office of Management and Budget, Neera Tanden, has withdrawn her nomination after she faced opposition from key Democratic and Republican senators for her controversial tweets.

Her withdrawal marks the first high-profile defeat of one of Biden's nominees. Eleven of the 23 Cabinet nominees requiring Senate approval have been confirmed, most with strong bipartisan support.

"Unfortunately, it now seems clear that there is no path forward to gain confirmation, and I do not want continued consideration of my nomination to be a distraction from your other priorities," Tanden wrote in a letter to Biden. The president, in a statement, said he has "utmost respect for her record of accomplishment, her experience and her counsel" and pledged to find her another role in his administration.

FILE - Sen. Joe Manchin, D-W.Va., speaks during a hearing on Capitol Hill in Washington, Feb. 24, 2021.

Tanden's viability was in doubt after Democratic West Virginia Sen. Joe Manchin and a number of moderate Republicans came out against her last month, all citing her tweets attacking members of both parties prior to her nomination.

Manchin, a key moderate swing vote in the Senate, said last month in a statement announcing his opposition that "her overtly partisan statements will have a toxic and detrimental impact on the important working relationship between members of Congress and the next director of the Office of Management and Budget."

FILE - Sen. Susan Collins, R-Maine, talks to reporters on Capitol Hill in Washington, Jan. 15, 2020.

Maine Republican Sen. Susan Collins, meanwhile, cited Biden's own standard of conduct in opposing Tanden, declaring in a statement that "her past actions have demonstrated exactly the kind of animosity that President Biden has pledged to transcend."

Tanden needed just 51 votes in an evenly divided Senate, with Vice President Kamala Harris acting as a tiebreaker. But without Manchin's support, the White House was left scrambling to find a Republican to support her.

FILE - Sen. Lisa Murkowski, R-Alaska, listens during a hearing on Capitol Hill, June 23, 2020.

One potential Republican vote, Sen. Lisa Murkowski of Alaska, told reporters earlier Tuesday on Capitol Hill she still had not yet made up her mind on Tanden's nomination.

The White House stuck with her even after several centrist Republicans made their opposition known, insisting her experience growing up on welfare and background working on progressive policies as the president and CEO of the liberal-leaning Center for American Progress made her the right candidate for the moment.

White House chief of staff Ron Klain initially insisted the administration was "fighting our guts out" for her.

100s of tweets deleted

FILE - Sen. Bernie Sanders, I-Vt., speaks during a hearing on Capitol Hill, Feb. 25, 2021.

Tanden faced pointed questions over her past comments about members from both parties during her confirmation hearing. Sen. Bernie Sanders, a Vermont independent and prominent progressive lawmaker, accused her of issuing "vicious attacks" against progressives, and had not said whether he would support her nomination.

Tanden apologized during that hearing to "people on either the left or right who are hurt by what I've said." Just prior to the hearing, she deleted hundreds of tweets, many of which were critical of Republicans.

Collins cited those deleted tweets in her statement, saying that the move "raises concerns about her commitment to transparency." She said Congress "has to be able to trust the OMB director to make countless decisions in an impartial manner, carrying out the letter of the law and congressional intent."

As recently as Monday, the White House indicated it was sticking by Tanden's nomination, with press secretary Jen Psaki noting Tanden's "decades of experience" in defending their pick.

"We will continue, of course, to fight for the confirmation of every nominee that the president puts forward," Psaki insisted. But she added, "We'll see if we have 50 votes."

Possible replacements

The head of the OMB is tasked with putting together the administration's budget, as well as overseeing a wide range of logistical and regulatory issues across the federal government.

Tanden's withdrawal leaves the Biden administration without a clear replacement. The apparent front-runner on Capitol Hill to replace Tanden was Shalanda Young, a former staff director for the House Appropriations Committee, who has been actively pushed by members of the Congressional Black Caucus.

Other names mentioned include Ann O'Leary, a former chief of staff for California Gov. Gavin Newsom, and Gene Sperling, who served as a top economic adviser to both Presidents Bill Clinton and Barack Obama.